Proteasome‐associated cysteine deubiquitinases are molecular targets of environmental optical brightener compounds
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چکیده
منابع مشابه
Molecular pathways: translational potential of deubiquitinases as drug targets.
The ubiquitin proteasome system (UPS) is the main system for controlled protein degradation and a key regulator of fundamental cellular processes. The dependency of cancer cells on a functioning UPS coupled with the clinical success of bortezomib for the treatment of multiple myeloma have made the UPS an obvious target for drug development. Deubiquitinases (DUB) are components of the UPS that e...
متن کاملMolecular Pathways Molecular Pathways: Translational Potential of Deubiquitinases as Drug Targets
The ubiquitin proteasome system (UPS) is the main system for controlled protein degradation and a key regulator of fundamental cellular processes. The dependency of cancer cells on a functioning UPS coupled with the clinical success of bortezomib for the treatment of multiple myeloma have made the UPS an obvious target for drug development. Deubiquitinases (DUB) are components of the UPS that e...
متن کاملDeubiquitinases: Novel Therapeutic Targets in Immune Surveillance?
Inflammation is a protective response of the organism to tissue injury or infection. It occurs when the immune system recognizes Pathogen-Associated Molecular Patterns (PAMPs) or Damage-Associated Molecular Pattern (DAMPs) through the activation of Pattern Recognition Receptors. This initiates a variety of signalling events that conclude in the upregulation of proinflammatory molecules, which i...
متن کاملInhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds
Copper and gold complexes have clinical activity in several diseases including cancer. Recently, we have reported that the anti-cancer activity of copper (II) pyrithione CuPT and gold (I) complex auranofin is associated with targeting the 19S proteasome-associated deubiquitinases (DUBs), UCHL5 and USP14. Here we discuss metal DUB inhibitors in treating cancer and other diseases. (from Editor). ...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2019
ISSN: 0730-2312,1097-4644
DOI: 10.1002/jcb.28682